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  • Longevity & Anti-Aging Interventions

    NAD+ Precursors (NMN vs NR) – What 2025 Data Show

    ByJack Holmes June 10, 2025

    Are you confused about which NAD+ booster actually works? You’re not alone. The science keeps evolving, and 2025 has brought game-changing research that’s reshaping how we think about these popular longevity supplements. Let’s cut through the noise and look at what the latest data really shows about NMN versus NR – your wallet and your…

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  • Longevity & Anti-Aging Interventions

    Combining Rapamycin + Trametinib: Synergy or Risk?

    ByJack Holmes June 10, 2025

    What if two powerful drugs could work together to slow aging better than either one alone? That’s the tantalizing question researchers are exploring with rapamycin and trametinib. These compounds target different but connected pathways in our cells that control aging. But like mixing ingredients in a chemistry experiment, combining potent drugs carries both promise and…

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  • Longevity & Anti-Aging Interventions

    GLP-1 Agonists (Ozempic, Wegovy) as Gerotherapeutics

    ByJack Holmes June 10, 2025

    Could a diabetes medication help you live longer? If youve been following health news lately, you’ve probably heard of Ozempic and Wegovy – those “miracle” weight loss shots everyone’s talking about. But theres something even more exciting happening with these drugs… something that could change the way we think about aging itself. Scientists are discovering…

    Read More GLP-1 Agonists (Ozempic, Wegovy) as GerotherapeuticsContinue

  • Longevity & Anti-Aging Interventions

    Metformin for Non-Diabetics: Pros, Cons & Dosage Guides

    ByJack Holmes June 10, 2025

    Want to know why a diabetes drug has become the darling of the biohacking world? Metformin is stepping out of the diabetes clinic and into the spotlight as a potential longevity hack. But should healthy people really take a prescription medication for its potential benefits? Let’s cut through the hype and look at what the…

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  • Longevity & Anti-Aging Interventions

    Low-Dose Rapamycin: Latest Human Trial Data & Side-Effects

    ByJack Holmes June 10, 2025

    Want to know what’s really happening with rapamycin research? The buzz around this potential longevity drug keeps growing, but sorting fact from hype can be tough. Let’s break down what the newest human trials actually show, the real side effects to watch for, and how it stacks up against other compounds people are using to…

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  • Longevity & Anti-Aging Interventions

    The Biohacker’s Longevity Stack: Evidence-Based Strategies in 2025

    ByJack Holmes June 10, 2025

    Your body has an expiration date. But what if you could push it back? Not with pseudoscience or magical thinking, but with compounds and protocols backed by real research. The science of extending human lifespan has exploded in the last five years. What was once fringe is now mainstream, with billions in research dollars and…

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  • Foundations of Biohacking

    The Ethics Debate: Where Self-Experimentation Crosses the Line

    ByJack Holmes June 10, 2025

    Dave injects himself with homemade gene therapy in his kitchen. Sarah implants a chip under her skin to track glucose levels. Michael microdoses LSD for “cognitive enhancement.” These aren’t sci-fi scenarios—they’re happening right now in garages, apartments, and makeshift labs across the world. Biohacking’s DIY ethos promises democratized science, but at what cost? When does…

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  • Foundations of Biohacking

    Women-Specific Biohacking Considerations (hormones, cycle syncing)

    ByJack Holmes June 10, 2025

    Ever thought your weird energy fluctuations, random cravings, and mood swings weren’t just random? They’re not. Your hormones follow a predictable pattern each month that affects EVERYTHING – how you feel, perform, sleep, and even how your body uses food. Most biohacking advice is built around men’s biology (surprise, surprise). But female bodies work differently….

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  • Foundations of Biohacking

    Budget Biohacking: 10 High-Impact Wins Under $100

    ByJack Holmes June 10, 2025

    Want better health, sharper thinking, and more energy without emptying your wallet? The biohacking world might seem full of expensive gadgets and exotic supplements, but the truth is, the most powerful health upgrades don’t require a second mortgage. I’ve tested hundreds of biohacks over the years, and the highest ROI interventions are often the least…

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  • Foundations of Biohacking

    Biohacking Risks & How to Vet Emerging Interventions

    ByJack Holmes June 10, 2025

    Imagine injecting yourself with an untested gene therapy in your garage, or implanting a homemade device under your skin. Sound extreme? For some biohackers, it’s just Tuesday. The promise of optimization is alluring, but the line between breakthrough and breakdown is thin. Whether you’re curious about nootropics or considering more advanced interventions, you need protection…

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