Biohacker’s Podcast: Nutritional Ketosis

Join Dr. Jeff Volek as he dives deep into his two decade-long obsession with the many ways the human body responds to elevated ketones!

Dr. Volek is a registered dietitian and professor in the Department of Human Sciences at The Ohio State University. For the last two decades, he has performed cutting edge research on how humans adapt to ketogenic diets with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 300 peer-reviewed scientific manuscripts and five books, and he has provided more than 200 lectures at scientific and industry conferences around the world.

His team at OSU is currently focused on breaking open new application related to nutritional ketosis. These studies are exploring the role of nutritional ketosis on cardio-metabolic status, ectopic fat accumulation in various tissues, tumor metabolism and health outcomes in various types of cancer, and human physical and cognitive capabilities in military personnel. Dr. Volek is the Chief Science Officer and Co-Founder of Virta Health, a specialty medical clinic that reverses type 2 diabetes safely and sustainably, without the risks, costs, or side effects of medications or surgery. Dr. Volek has a Bachelor of Science in dietetics from Michigan State University, and a Master of Science in exercise physiology and Doctorate in kinesiology and nutrition from Pennsylvania State University.

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Summary and takeaways:

00:06 Introduction by Teemu Arina: the basics of ketosis
01:58 Teemu introduces Dr. Jeff Volek
03:07 Beginning of Dr. Jeff Volek’s presentation
04:35 Quick history on ketones
05:26 The Golden Age of ketones (now)
05:59 A primer on ketosis
09:35 Ketogenic adaptation and fat burning
11:41 Various methods of inducing ketosis
12:47 Misconceptions about the ketogenic diet
13:56 Clinical targets and applications of ketogenic diets
14:09 Obesity crisis in the US & potential diabetes risks
15:56 Ketosis vs. biomarkers
17:22 Type-2 diabetes study
19:14 Insane diet recommendations for diabetics
19:43 Cancers vs. glucose
21:06 Metastatic breast cancer trials
21:51 Patient testimonial
23:02 Tumor regression
23:46 Neurological conditions, epilepsy, seizures
24:15 Your brain prefers ketones
25:21 Does the brain function more efficiently on ketones?
25:47 Protection from hypoglycemia
26:32 Neurocognitive performance improves
27:03 Alzheimer’s insights
28:17 Traumatic Brain Injuries and paratroopers
29:13 Applications in sports and miliary
31:01 Study involving high-level athletes
31:52 Fat oxidation in athletes on keto
32:24 Glycogen levels maintained on keto: why?
33:37 Obesity as a national security risk
34:37 Unpublished (as of 2018) study & results
37:28 Teemu thanks Dr. Volek
37:39 Things to consider when attempting a ketogenic diet
39:13 What is “keto-flu” and how to prevent it
40:36 Cardiovascular biomarkers improve despite high fat content
41:07 Strict vs. cyclical ketogenic diet (especially important for women!)
42:30 Electrolyte product recommendations

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